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Venoms of South Asian hump-nosed pit vipers (Genus: Hypnale) cause muscarinic effects in BALB/c mice

Authors:

A Silva ,

Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka., LK
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D Weilgama,

Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka., LK
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I Gawarammana,

Department of Medicine, Faculty of Medicine, University of Peradeniya, LK
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P Gunawardena

Department of Veterinary Pathobiology, faculty of Veterinary Medicine and Animal Science, University of Peradeniya., LK
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Abstract

Although clinical, in-vivo and in-vitro studies suggest the necrotic, haemorrhagic, pro-coagulant and nephrotoxic effects of South Asian Hump nosed pit vipers, reports on neurotoxic properties are limited to a single in-vitro study. Using BALB/c mice, for the first time, here we demonstrate the signs of envenoming suggestive of possible muscarinic effects of the venoms of all three Hypnale species. Further, we demonstrate that the muscarinic effects are occurred at lower venom doses by H. hypnale venom, compared to H. nepa and H. zara.

DOI: http://dx.doi.org/10.4038/amj.v8i1.6754

Anuradhapura Medical Journal 2014; 8(1):13-15

How to Cite: Silva, A. et al., (2014). Venoms of South Asian hump-nosed pit vipers (Genus: Hypnale) cause muscarinic effects in BALB/c mice. Anuradhapura Medical Journal. 8(1), pp.13–15. DOI: http://doi.org/10.4038/amj.v8i1.6754
Published on 30 Mar 2014.
Peer Reviewed

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