Research Articles
Differentiating healthy and mesial temporal lobe epileptic (MTLE) brains by analyzing the adjusted volume of the hippocampus using Magnetic Resonance Imaging (MRI)
Authors:
L. R. S. Rathnakumara,
University of Peradeniya, Peradeniya, LK
About L. R. S.
Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences
B. G. S. Nadeeshan,
University of Peradeniya, Peradeniya, LK
About B. G. S.
Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences
I. U. Wickramarathne,
University of Peradeniya, Peradeniya, LK
About I. U.
Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences
Sahan M. Vijithananda,
Rajarata University, LK
About Sahan
Department of Anatomy, Faculty of Medicine and Allied Sciences
Anil De Silva,
National Hospital of Sri Lanka, Colombo, LK
About Anil
Epilepsy Unit
Manjula de Silva,
University of Ruhuna, LK
About Manjula
Department of Physics, Faculty of Science
Padma B. Hewavithana,
University of Peradeniya, LK
About Padma
Department of Radiology, Faculty of Medicine
Mohan L. Jayatilake
University of Peradeniya, Peradeniya, LK
About Mohan L.
Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences
Abstract
Epilepsy is one of the most affecting neurological diseases that occur due to an abnormal, uncontrolled firing of a group of neurons in the brain. The temporal lobe is the most common epileptogenic site of humans, with mesial temporal lobe epilepsy (MTLE) being the most common type in adults. MRI plays a major role in diagnostic and therapeutic procedures of MTLE. This study focused on calculating the adjusted volume of human hippocampus by measuring the volumes of the cerebrum and hippocampus and utilizing them to identify the correlation of adjusted volume distribution patterns among MTLE and healthy subjects.
The study was carried out using MR images of ten subjects, five MTLE and five healthy, who are within the 20-30 age range. All the MR Digital Imaging and Communications in Medicine (DICOM) images were acquired from a 3-Tesla Siemens MRI facility, and each subject’s pathology was confirmed by radiological reports.
The study has acquainted a semi-automated method to investigate volume differences in hippocampus between healthy and MTLE subjects using hippocampal volume as a potential biomarker. The adjusted volumes of hippocampus were calculated as a proportion of the brain volume. Finally, the volume values received for each category were tested with a one-tailed t-test.
The mean adjusted hippocampal volume of epilepsy and normal subjects were reported as 0.01011 ± 0.00127 and 0.011709 ± 0.000659 respectively. The t-test revealed that there is a significantly low, mean adjusted hippocampal volume for MTLE subjects than the healthy population; t-stat (2.56) > t-critical (2.13). Therefore, the study suggests the application of adjusted hippocampal volume as a potential biomarker to identify MTLE patients.
How to Cite:
Rathnakumara, L.R.S., Nadeeshan, B.G.S., Wickramarathne, I.U., Vijithananda, S.M., De Silva, A., de Silva, M., Hewavithana, P.B. and Jayatilake, M.L., 2023. Differentiating healthy and mesial temporal lobe epileptic (MTLE) brains by analyzing the adjusted volume of the hippocampus using Magnetic Resonance Imaging (MRI). Anuradhapura Medical Journal, 17(1), pp.54–61. DOI: http://doi.org/10.4038/amj.v17i1.7739
Published on
01 May 2023.
Peer Reviewed
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